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Staphylococcus aureus 1

Staphylococcus cohnii 1

ADAM10 inhibitor 1

Bacterial toxins 1

Barrier disruption 1

Host-directed therapy 1

Kaempferol 1

Nanoparticle 1

Nanosponge 1

Necroptosis 1

Nicotineamide adenine dinucleotide-dichlorophenol indophenol (NADH-DCIP) reductase 1

Platelet 1

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Staphylococcus aureus infection 1

azoreductase 1

decolorization 1

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Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity Article

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Engineering 2021, Volume 7, Issue 8,   Pages 1149-1156 doi: 10.1016/j.eng.2020.09.013

Abstract:

Staphylococcus (S.)aureus is a leading human pathogen capable of producing severe invasive infections such as bacteremiaS. aureus pathogenesis is fueled by the secretion of toxins—such as the membrane-damaginghuman platelet membrane-coated nanoparticles (PNPs) as a biomimetic decoy strategy to neutralize S. aureusThe PNPs blocked platelet damage induced by S. aureus secreted toxins, thereby supporting platelet

Keywords： Nanoparticle     Nanosponge     Platelet     Staphylococcus aureus     Bacterial toxins     Sepsis    

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Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus Article

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Engineering 2023, Volume 28, Issue 9,   Pages 206-221 doi: 10.1016/j.eng.2023.03.006

Abstract:

Host-directed therapy (HDT) is an emerging novel approach for treating multidrug-resistant Staphylococcusaureus (S. aureus) infection.The extraordinary contribution of ADAM10 to S. aureus pathogenesis renders it an attractiveHDT target for combating S. aureus infection.necroptosis, and it enhances our knowledge of the role of ADAM10 in S. aureus infection.

Keywords： Host-directed therapy     Kaempferol     ADAM10 inhibitor     Staphylococcus aureus infection     Barrier disruption    

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Decolorization of azo dyes by a salt-tolerant

Bin YAN, Cuihong DU, Meilan XU, Wenchao LIAO

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 6,   Pages 806-814 doi: 10.1007/s11783-012-0453-4

Abstract: The salt-tolerant strain, isolated from textile wastewater, has been found effective on decolorizing several kinds of azo dyes with different structures. The optimal conditions for azo dye acid red B (ARB) decolorization by were determined to be pH= 7.0 and 30°C. The decolorization efficiency increased with the increase of the salinity concentration, and around 90% of ARB (100 mg·L ) could be decolorized in 24 h when the salinity concentration was up to 50 g·L . Moreover, the strain could still decolorize 19% of ARB in 24 h even when the NaCl concentration was increased to 150 g·L . Meanwhile, the dependence of the specific decolorization rate by on the ARB concentration could be described with Michaelis-Menten kinetics ( = 585.7 mg·L , = 109.8 mg·g cell ·h ). The addition of quinone redox mediator, named 2-hydroxy-1,4-naphthoquinone and anthraquinone-2,6-disulfonate, significantly accelerated the decolorization performance of . Furtherly, the activities of azoreductase (0.55 μmol·mg protein ·min ) and Nicotineamide adenine dinucleotide-dichlorophenol indophenol (NADH-DCIP) reductase (8.9 μmol·mg protein ·min ) have been observed in the crude cell extracts of . The decolorization products of ARB were analyzed by HPLC-MS, and the results indicated the reductive pathway was responsible for azo dye decolorization by .

Keywords： Staphylococcus cohnii     decolorization     salt     azoreductase     Nicotineamide adenine dinucleotide-dichlorophenol    

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Title Author Date Type Operation

Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Journal Article

Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Journal Article

Decolorization of azo dyes by a salt-tolerant

Bin YAN, Cuihong DU, Meilan XU, Wenchao LIAO

Journal Article